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How does Ovarifert help with PCOS?
Ovarifert by amitamin® is a dietary supplement for women with Polycystic Ovary Syndrome (PCOS), a common health condition. Ovarifert has been specially formulated to support ovulation in women with PCOS.
One of the main effects of PCOS is that it causes problems with ovulation, which results in irregular periods. PCOS can also result in women having multiple ‘cysts’ on their ovaries and a hormonal imbalance.
The hormones typically affected are male hormones, which are present in women and include testosterone. The levels of these hormones are higher than usual in women with PCOS.
Women do not need to have all of these features to be diagnosed with PCOS, and the symptoms can drastically vary between women. The most common symptoms include fertility problems, excess unwanted hair growth and weight gain.
Causes of PCOS
The exact cause of PCOS is not clear. However scientists have found that fertility problems in PCOS are the result of a number of key factors.
These include raised blood sugar control hormone levels and blood sugar control hormone resistance (for more information on why this affects female fertility, please see ALA below). In addition to this, the excess levels of male hormones can interfere with normal ovulation in women with PCOS.
Ovarifert is tailored to address these problems and therefore improve female fertility. There is no cure for PCOS but Ovarifert aims to support ovulation and successful conception in women affected by PCOS.
How does Ovarifert work?
Ovarifert contains a number of nutrients which have been investigated by scientists, and there is evidence supporting their use in women with PCOS. These are not hormones and are safe to use as they are classed as food products.
Click on each of the main therapeutic components of Ovarifert to find out more:
Scientists have studied myo-inositol and they have found that it can improve fertility in PCOS patients by restoring normal ovulation 1. It can also reduce the levels of blood sugar control hormone and male hormones in the body 2.
Therefore it is not surprising that many PCOS supplements contain this compound. However not all of them contain sufficient quantities of myo-inositol to actually have an effect. Generally it is recommended to take 2000mg- 4000mg of myo-inositol per day to experience any improvement in PCOS symptoms.
Ovarifert contains 2000mg of myo-inositol per daily dose, which is at the lower end of the recommended range. Nevertheless scientists have found that this amount can still have positive effects in women with PCOS, particularly in terms of fertility 3. It is also important to consider that there are many other PCOS supplements available which contain far less myo-inositol than Ovarifert.
Our bodies naturally produce both myo-inositol and D-chiro-inositol. With the help of an enzyme, the body converts myo-inositol into D-chiro-inositol. D-chiro-inositol helps to restore hormonal balance and improve fertility in PCOS.
Clinical studies have shown that increasing the intake of inositol in supplements can have beneficial effects in PCOS. Some studies have used 4000mg per day of myo-inositol, and they have reported improved fertilisation rates for IVF 4. Additionally, scientists found that including both myo-inositol and D-chiro-inositol in supplementation resulted in a greater beneficial effect in PCOS patients than myo-inositol alone 5 6.
This is because D-chiro-inositol works in combination with myo-inositol, so that it reduces the amount of myo-inositol needed to have an effect in the body. It can also encourage the beneficial effects due to myo-inositol to occur at a faster rate.
Despite this, many PCOS supplements only include myo-inositol and not D-chiro-inositol. Ovarifert is one of the few PCOS supplements which contain both of these forms of inositol.
Ovarifert contains 250mg of D-chiro-inositol per daily dose. Research into this nutrient is ongoing, but scientists have already found an improvement in fertility using a much lower dose of 27.6mg of D-chiro-inositol in women with PCOS 7. Therefore the amount of D-chiro-inositol in Ovarifert is likely to have a therapeutic effect in PCOS in combination with myo-inositol.
Alpha-lipoic acid (ALA)
Alpha-lipoic acid, or ALA, is an antioxidant. It can help to improve blood sugar control hormone sensitivity in women with PCOS.
Blood sugar control hormone is obviously important for blood glucose control. The pancreas produces blood sugar control hormone when blood glucose levels rise after a meal. blood sugar control hormone signals the cells in the body to take in glucose and use it as energy. However women with PCOS typically tend to have higher blood sugar control hormone levels and this causes their cells to become less sensitive to it.
This develops into blood sugar control hormone resistance, where higher levels of this hormone are needed to have any effect in the body. But higher levels of blood sugar control hormone can interfere with fertility, as it can cause the ovaries to produce more testosterone than usual. Testosterone can interfere with the follicles in the ovaries, which in turn hinders normal ovulation.
Scientists investigating alpha-lipoic acid have found that it can improve blood sugar control hormone sensitivity in women with PCOS 8. But Ovarifert only contains 150mg of alpha-lipoic acid per daily dose. Studies have found improvements in blood sugar control hormone sensitivity using higher doses of 1200mg of alpha-lipoic acid 9.
Therefore it is not clear whether the amount of alpha lipoic acid in Ovarifert is enough to have an effect in women with PCOS. It does, however, include the highest amount of ALA of all the PCOS supplements we researched on the market.
Homocysteine is an amino acid which is present in high levels in women with PCOS. It increases the risk of developing cardiovascular diseases including heart attacks and strokes and it is also linked with high blood sugar control hormone levels in PCOS patients.
Additionally, high levels of homocysteine are related to an increased likelihood of suffering from a miscarriage 10. However research suggests that betaine may help to lower the levels of homocysteine in the blood 11.
Pine bark extract
Pine bark extract can help to control blood glucose and manage metabolic syndrome.
Metabolic syndrome is a combination of high blood pressure, obesity, and abnormal triglyceride levels which all increase the risk of developing heart disease and other problems which affect blood vessels.
Women with PCOS are more likely to develop metabolic syndrome. However pine bark extract can help to reduce features of metabolic syndrome including waist circumference and blood pressure 12.
Vitamin C can help to support ovulation in women. It can also help to lower cholesterol levels 13 which are commonly a problem in patients with PCOS.
Scientists have found that vitamin E can help to improve blood sugar control hormone sensitivity in women with PCOS. Additionally it can reduce testosterone levels, which in turn supports normal ovulation 14.
Vitamin D can help to reduce blood sugar control hormone resistance 15. Scientists have also studied its effects in infertile women with PCOS and they found that it can improve follicle development and menstrual regularity 16. Additionally vitamin D is important in protecting against problems during pregnancy 17.
How and when should you take Ovarifert?
The daily dose of Ovarifert consists of four tablets. The manufacturer amitamin® recommends taking the daily dose in one sitting without splitting up the dose throughout the day in order to maximise the beneficial effects.
Additionally you should take Ovarifert either with or before a meal. Each box contains 120 capsules and it will provide enough capsules for 30 days.
amitamin® recommends taking Ovarifert for an extended period of time to gain the full benefit. They advise customers to use Ovarifert for a minimum of three months, or until they are able to conceive.
This is because the quantities of the nutrients are low enough to have a gradual and safe effect on the body. Altering the hormonal balance in the body can be difficult as the body can compensate for changes in nutrient intake. Therefore it takes time to improve this balance and ensure that the benefits last long enough to enable successful conception.
How much does Ovarifert cost?
The price of amitamin® Ovarifert decreases as you buy more boxes of the product. For two boxes (two months’ supply) the cost is £34.95 per box, and for three boxes (three months’ supply) the cost is £29.95 per box. Shipping is free for customers in the UK and many other countries.
You can buy amitamin® Ovarifert from registered pharmacies, or directly online here.
Advantages of Ovarifert
Disadvantages of Ovarifert
There are a huge number of supplements available on the market for women with PCOS. These contain a range of different ingredients, but Ovarifert combines the ingredients with the strongest scientific evidence supporting their use into one product.
There are other products available which contain a greater number of nutrients in higher quantities, but at a much higher cost. Overall Ovarifert is excellent value for money. It is much cheaper to spend £1 per day on nutrient supplements than thousands of pounds on hormone and other fertility treatments.
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- Unfer V, Nestler JE, Kamenov ZA, Prapas N, Facchinetti F. Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials. International Journal of Endocrinology. Internet. 2016. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097808/ ↩
- Unfer V, Facchinetti F, Orru B, Giordani B, Nestler J. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrinology Connections. Internet. 2017. 6(8):647-658. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655679/ ↩
- Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of Myo-Inositol supplementation on oocyte’s quality in PCOS patients: a double blind trial. European Review for Medical and Pharmacological Sciences. Internet. 2011. 15. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.458.6816&rep=rep1&type=pdf ↩
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- Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. European Review for Medical and Pharmacological Sciences. Internet. 2012. 16(5):575-81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22774396 ↩
- Colazingari S, Treglia M, Najjar R, Bevilacqua A. The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Archives of Gynaecology and Obstetrics. Internet. 2013. 288(6):1405-1411. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23708322 ↩
- Genazzani AD, Shefer K, Della Casa D, Prati A, Napolitano A, Manzo A, Despini G, Simoncini T. Modulatory effects of alpha-lipoic acid (ALA) administration on blood sugar control hormone sensitivity in obese PCOS patients. Journal of Endocrinological Investigation. Internet. 2018. 41(5):583-590. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29090431 ↩
- Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID. Effects of Controlled-Release Alpha Lipoic Acid in Lean, Nondiabetic Patients with Polycystic Ovary Syndrome. Journal of Diabetes Science and Technology. Internet. 2010. 4(2):359-364. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864173/ ↩
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