Ovarifert contains many nutrients which are scientifically proven to help women with PCOS, specifically myo-inositol and D-chiro-inositol and is overall good value for money.
For a complete range of pre-pregnancy nutrients we suggest taking Ovarifert in combination with Fertil F, omega-3 from fish or algae, and N-acetylcysteine (NAC) at a combined cost of £2 per day.
How does Ovarifert help with PCOS?
Ovarifert by amitamin® is a dietary supplement for women with Polycystic Ovary Syndrome (PCOS), a common health condition. Ovarifert has been specially formulated to support ovulation in women with PCOS.
One of the main effects of PCOS is that it causes problems with ovulation, which results in irregular periods. PCOS can also result in women having multiple ‘cysts’ on their ovaries and a hormonal imbalance.
The hormones typically affected are male hormones, which are present in women and include testosterone. The levels of these hormones are higher than usual in women with PCOS.
Women do not need to have all of these features to be diagnosed with PCOS, and the symptoms can drastically vary between women. The most common symptoms include fertility problems, excess unwanted hair growth and weight gain.
Causes of PCOS
The exact cause of PCOS is not clear. However scientists have found that fertility problems in PCOS are the result of a number of key factors.
These include raised insulin levels and insulin resistance (for more information on why this affects female fertility, please see ALA below). In addition to this, the excess levels of male hormones can interfere with normal ovulation in women with PCOS.
Ovarifert is tailored to address these problems and therefore improve female fertility. There is no cure for PCOS but Ovarifert aims to support ovulation and successful conception in women affected by PCOS.
How does Ovarifert work?
Ovarifert contains a number of nutrients which have been investigated by scientists, and there is evidence supporting their use in women with PCOS. These are not hormones and are safe to use as they are classed as food products.
Click on each of the main therapeutic components of Ovarifert to find out more:
How and when should you take Ovarifert?
The daily dose of Ovarifert consists of four tablets. The manufacturer amitamin® recommends taking the daily dose in one sitting without splitting up the dose throughout the day in order to maximise the beneficial effects.
Additionally you should take Ovarifert either with or before a meal. Each box contains 120 capsules and it will provide enough capsules for 30 days.
amitamin® recommends taking Ovarifert for an extended period of time to gain the full benefit. They advise customers to use Ovarifert for a minimum of three months, or until they are able to conceive.
This is because the quantities of the nutrients are low enough to have a gradual and safe effect on the body. Altering the hormonal balance in the body can be difficult as the body can compensate for changes in nutrient intake. Therefore it takes time to improve this balance and ensure that the benefits last long enough to enable successful conception.
How much does Ovarifert cost?
The price of amitamin® Ovarifert decreases as you buy more boxes of the product. For two boxes (two months’ supply) the cost is £34.95 per box, and for three boxes (three months’ supply) the cost is £29.95 per box. Shipping is free for customers in the UK and many other countries.
You can buy amitamin® Ovarifert from registered pharmacies, or directly online here.
Advantages of Ovarifert
Disadvantages of Ovarifert
There are a huge number of supplements available on the market for women with PCOS. These contain a range of different ingredients, but Ovarifert combines the ingredients with the strongest scientific evidence supporting their use into one product.
There are other products available which contain a greater number of nutrients in higher quantities, but at a much higher cost. Overall Ovarifert is excellent value for money. It is much cheaper to spend £1 per day on nutrient supplements than thousands of pounds on hormone and other fertility treatments.
Use Ovarifert by amitamin® for at least three months to improve your fertility. Remember to ask your GP’s advice for any other methods to maximise your chances of conceiving and check that any other medicines you take will not interact with Ovarifert.
If you are actively trying to conceive we would recommend adding a pre-pregnancy supplement with folate, as well as omega-3 and NAC.
Both of these are included in some other supplement products such as Fertilovit F PCOS by Fertilovit (click here for more details). However, Fertilovit F PCOS is also double the price of Ovarifert. It is therefore more cost-effective to take omega-3 and NAC separately. Make sure you consume a minimum dose of 3g per day of omega-3, and 1g per day of NAC.
In summary: we would recommend taking the following products together for a full spectrum pre-pregnancy nutrient supply.
• Amitamin Fertil F
• Omega-3 from fish or algae if you prefer a vegan product (If you live outside the UK, please search for similar products online or ask your local pharmacist).
• NAC (Cysteine) (If you live outside the UK, please search for similar products online or ask your local pharmacist).
The combination of the above four products will statistically increase female fertility at a cost of approximately £2 per day.
Keep in mind that fertility treatment costs at fertility clinics are significantly higher.
- Unfer V, Nestler JE, Kamenov ZA, Prapas N, Facchinetti F. Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials. International Journal of Endocrinology. Internet. 2016. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097808/ ↩
- Unfer V, Facchinetti F, Orru B, Giordani B, Nestler J. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrinology Connections. Internet. 2017. 6(8):647-658. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655679/ ↩
- Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of Myo-Inositol supplementation on oocyte’s quality in PCOS patients: a double blind trial. European Review for Medical and Pharmacological Sciences. Internet. 2011. 15. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.458.6816&rep=rep1&type=pdf ↩
- Regidor PA, Schindler AW, Lesoine B, Druckman R. Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature. Hormone Molecular Biology and Clinical Investigation. Internet. 2018. 34(2). Available from: https://www.ncbi.nlm.nih.gov/pubmed/29498933 ↩
- Bevilacqua A, Bizzarri M. Physiological role and clinical utility of inositols in polycystic ovary syndrome. Best Practice and Research: Clinical Obstetrics and Gynaecology. Internet. 2016. 37:129-139. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27117028 ↩
- Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. European Review for Medical and Pharmacological Sciences. Internet. 2012. 16(5):575-81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22774396 ↩
- Colazingari S, Treglia M, Najjar R, Bevilacqua A. The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Archives of Gynaecology and Obstetrics. Internet. 2013. 288(6):1405-1411. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23708322 ↩
- Genazzani AD, Shefer K, Della Casa D, Prati A, Napolitano A, Manzo A, Despini G, Simoncini T. Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients. Journal of Endocrinological Investigation. Internet. 2018. 41(5):583-590. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29090431 ↩
- Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID. Effects of Controlled-Release Alpha Lipoic Acid in Lean, Nondiabetic Patients with Polycystic Ovary Syndrome. Journal of Diabetes Science and Technology. Internet. 2010. 4(2):359-364. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864173/ ↩
- Nelen WLDM, Blom HJ, Steegers EAP, Heijer MD, Eskes TKAB. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertility and Sterility. Internet. 2000. 74(6):1196-1199. Available from: https://www.sciencedirect.com/science/article/pii/S0015028200015958 ↩
- Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current Drug Metabolism. Internet. 2005. 6(1):15-22. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15720203 ↩
- Belcaro G, Cornelli U Cesarone MR, Dugall M, Feragalli B, Errichi S, Ippolito E, Grossi MG, Hosoi M, Cornelli M, Gizzi G. Pycnogenol® supplementation improves health risk factors in subjects with metabolic syndrome. Phytotherapy Research. Internet. 2013. 27(10):1572-1578. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23359520 ↩
- McRae MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. Journal of Chiropractic Medicine. Internet. 2008. 7(2):48-58. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682928/ ↩
- Ebrahimi FA, Samimi M, Foroozanfard F, Jamilian M, Akbari H, Rahmani E, Ahmadi S, Taghizadeh M, Memarzadeh MR, Asemi Z. The effects of omega-3 fatty acids and vitamin E co-supplementation on indices of IR and hormonal parameters in patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology and Diabetes. Internet. 2017. 125(6):353-359. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28407657 ↩
- Parildar H, Cigerli O, Unal DA, Gulmez O, Demirag NG. The impact of vitamin D replacement on glucose metabolism. Pakistan Journal of Medical Sciences. Internet. 2013. 29(6):1311-1314. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905396/ ↩
- Firouzabadi RD, Aflatoonian A, Modarresi S, Sekhavat L, Taheri SM. Therapeutic effects of calcium and vitamin D supplementation in women with PCOS. Complementary Therapies in Clinical Practice. Internet. 2012. 18(2):85-88. Available from: https://www.sciencedirect.com/science/article/pii/S1744388112000060 ↩
- Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality- A review of recent evidence. Autoimmunity Reviews. Internet. 2013. 12(1):976-989. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1568997213000402 ↩
- Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, Magni F, Sandoli EP, Lucotti P, Costa S, Galli-Kienle M, Origgi A, Margonato A, Piatti P. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinaemia. European Journal of Endocrinology. Internet. 2004. 151(4):483-489. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15476449 ↩
- Bennett M. Vitamin B12 deficiency, infertility and recurrent fetal loss. Journal of Reproductive Medicine. Internet. 2001. 46(3):209-212. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11304860 ↩